{"id":1295,"date":"2018-02-21T17:03:21","date_gmt":"2018-02-21T17:03:21","guid":{"rendered":"http:\/\/homestead.test\/?p=1295"},"modified":"2023-11-21T13:08:54","modified_gmt":"2023-11-21T13:08:54","slug":"cell-therapy","status":"publish","type":"post","link":"https:\/\/mastercellbank.com\/archive\/cell-therapy","title":{"rendered":"Cell Therapy"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:1px;padding-right:0px;padding-bottom:1px;padding-left:0px;margin-bottom: 0px;margin-top: 0px;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-content-boxes content-boxes columns row fusion-columns-1 fusion-columns-total-1 fusion-content-boxes-1 content-boxes-icon-with-title content-left\" data-animationOffset=\"100%\" style=\"margin-top:1px;margin-bottom:1px;\"><style type=\"text\/css\">.fusion-content-boxes-1 .heading .content-box-heading {color:#333333;}\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover .heading .content-box-heading,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover .heading .heading-link .content-box-heading,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover .heading .content-box-heading,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover .heading .heading-link .content-box-heading,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover.link-area-box .fusion-read-more,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover.link-area-box .fusion-read-more::after,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover.link-area-box .fusion-read-more::before,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .fusion-read-more:hover:after,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .fusion-read-more:hover:before,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .fusion-read-more:hover,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover.link-area-box .fusion-read-more,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover.link-area-box .fusion-read-more::after,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover.link-area-box .fusion-read-more::before,\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover .icon .circle-no,\n\t\t\t\t\t.fusion-content-boxes-1 .heading .heading-link:hover .content-box-heading {\n\t\t\t\t\t\tcolor: #5f88a0;\n\t\t\t\t\t}\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover .icon .circle-no {\n\t\t\t\t\t\tcolor: #5f88a0 !important;\n\t\t\t\t\t}.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box.link-area-box-hover .fusion-content-box-button {background: #478eb9;color: #23b1ee;}.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box.link-area-box-hover .fusion-content-box-button .fusion-button-text {color: #23b1ee;}\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover .heading .icon > span {\n\t\t\t\t\t\tbackground-color: #5f88a0 !important;\n\t\t\t\t\t}\n\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover .heading .icon > span {\n\t\t\t\t\t\tborder-color: #5f88a0 !important;\n\t\t\t\t\t}<\/style><div class=\"fusion-column content-box-column content-box-column content-box-column-1 col-lg-12 col-md-12 col-sm-12 fusion-content-box-hover content-box-column-last content-box-column-last-in-row\"><div class=\"col content-box-wrapper content-wrapper-background link-area-link-icon icon-hover-animation-fade\" style=\"background-color:rgba(216,216,216,0.93);\" data-animationOffset=\"100%\"><div class=\"heading icon-left\"><h2 class=\"content-box-heading\" style=\"font-size:18px;line-height:23px;\">About Master Cell Bank \/ Biost\u00f3r<\/h2><\/div><div class=\"fusion-clearfix\"><\/div><div class=\"content-container\" style=\"color:#747474;\">\n<p>Biost\u00f3r \/ Master Cell Bank is a leading EU-licensed Tissue Establishment (TE) storing life-saving cell therapies, GMP Cell Banks and Clinical Trial samples since 2007. Serving global markets, it provides cell and tissue biostorage and cold chain logistics solutions to many leading medical and biotechnology research organisations world-wide. Call +353-539161398, email info@biostor.eu or <a href=\"\/contact\">enquire<\/a><\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">\n\t\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .heading-link:hover .icon i.circle-yes,\n\t\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box:hover .heading-link .icon i.circle-yes,\n\t\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-link-icon-hover .heading .icon i.circle-yes,\n\t\t\t\t\t\t.fusion-content-boxes-1 .fusion-content-box-hover .link-area-box-hover .heading .icon i.circle-yes {\n\t\t\t\t\t\t\tbackground-color: #5f88a0 !important;\n\t\t\t\t\t\t\tborder-color: #5f88a0 !important;\n\t\t\t\t\t\t}<\/style><div class=\"fusion-clearfix\"><\/div><\/div><div class=\"fusion-text fusion-text-1\"><p>Cell therapy, cytotherapy, cytotherapeutics has the potential to provide cures for many significant ailments and disorders by repairing and reversing disease through regenerative medicine. The clinical application cells began in 1956 with the first successful bone marrow transplant, performed between twins, with bone marrow taken from the healthy identical twin, and given to the other, who had leukaemia.<\/p>\n<p>Peripheral blood stem cell transplantations (PBSCT) are now the most common cell therapy procedure. Its clinical introduction in 1986 replaced bone marrow (BM) as a stem cell source to almost 100% in the and to autologous approximately 75% in the allogeneic transplant setting.<\/p>\n<p>The first successful cord blood stem cell transplant was performed 30 years ago in October 1988 with a boy with Fanconi anemia. Cord blood stem cell transplants have now been successfully given to treat patients with more than 70 diseases. It is estimated that there are over 600\u2009000 UCB units stored worldwide, and &gt;30\u2009000 UCBTs have been performed. Cord blood is now being enriched with functional stem and progenitor cells and also immune modulatory cells. Talk to us today about <a href=\"https:\/\/mastercellbank.com\/contact\" target=\"_blank\" rel=\"noopener\">cord blood banking or DNA storage<\/a>.<\/p>\n<p>A new cell therapy, donor lymphocyte infusion, emerged in the 1990s to ensure that the donor stem cells remain engrafted whereby lymphocytes from the blood of a donor are given to a patient who has already received a hematopoietic stem cells from the same donor.<\/p>\n<p><img decoding=\"async\" class=\"lazyload alignleft wp-image-1307 size-full\" src=\"https:\/\/mastercellbank.com\/wp-content\/uploads\/2018\/02\/microvesicles.png\" data-orig-src=\"https:\/\/mastercellbank.com\/wp-content\/uploads\/2018\/02\/microvesicles.png\" alt=\"Microvesicles - cord blood banking - DNA storage \" width=\"471\" height=\"281\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27471%27%20height%3D%27281%27%20viewBox%3D%270%200%20471%20281%27%3E%3Crect%20width%3D%27471%27%20height%3D%27281%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/mastercellbank.com\/wp-content\/uploads\/2018\/02\/microvesicles-200x119.png 200w, https:\/\/mastercellbank.com\/wp-content\/uploads\/2018\/02\/microvesicles-300x179.png 300w, https:\/\/mastercellbank.com\/wp-content\/uploads\/2018\/02\/microvesicles-400x239.png 400w, https:\/\/mastercellbank.com\/wp-content\/uploads\/2018\/02\/microvesicles.png 471w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 471px) 100vw, 471px\" \/><\/p>\n<p>Mesenchymal stem cells (MSCs) the most significant stem cells for cell therapy were first isolated and characterized in 1974 and have been used in the clinic since 2004. MSCs are multipotent stromal cells that make and restore skeletal tissue and can differentiate into diverse cell types: bone, cartilage, muscle and fat.<\/p>\n<p>Bone marrow was the original and most common source of MSCs and they are also found in Wharton\u2019s Jelly, Cord Blood, Adipose Tissue, Molar Teeth, Amniotic Fluid and Peripheral Blood.<\/p>\n<p>Today, there are about 500 clinical trials investigating their therapeutic uses in treating haematological diseases, GVHD, diabetes, inflammatory diseases, and diseases in the liver, kidneys, and lungs, as well as cardiovascular, bone and cartilage, neurological, and autoimmune diseases.<\/p>\n<p>To date one cellular immunotherapy has been approved by the FDA in 2010 and the EMA in 2013 for asymptomatic or minimally symptomatic metastatic castrate resistant prostate cancer: Dendreon\u2019s Sipuleucel-T (Provenge)<\/p>\n<p>Hematopoietic stem cells (HSCs) used in the treatment of cancers and other immune system disorders are found in the red bone marrow in the central part of most bones but principally in the pelvis, femur, and sternum. HSCs give rise to a variety of blood cells: monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, dendritic cells, platelets. T cells, B cells, and natural killer cells.<\/p>\n<p>Induced pluripotent stem cells (iPSCs) are a type of stem cells that can be generated directly from adult cells and pioneered by Yamanaka in 2006 who discovered that only 4 genes were required to re-programme adult cells into iPSCs. iPSC derived from MSCs are multi-lineage and less immunoreactive and show future promise for cancer treatment. Human iPSC derived cardiovascular and neuronal cells are being used in preclinical studies and will find use in clinical application as cell therapies. In addition, manufacturing human platelets from iPSCs, ex vivo in bioreactors will create an abundant supply of cell therapies that resolve limitations in the safety and supply of transfusion products<\/p>\n<p>The cell therapy industry is rapidly expanding. Hardly a day goes by without hearing of some new cell involved in a new disease treatment: Numerous cellular immunotherapies are currently in clinical development, using natural killer cells, dendritic cells (DCs), macrophages, polyclonal or antigen-specific T cells and lymphokine-activated killer cells.<\/p>\n<p>Stem cell-derived dopamine neurons for brain repair in Parkinson&#8217;s disease. Neural progenitor cells derived from bone marrow mesenchymal stem cells (called MSC-NPs) for treatment of MS; allogenic natural killer cells (NK-cells) generated ex vivo from umbilical cord blood progenitor cells in cancer immunotherapy. MSCs derived from placenta for the treatment of critical limb ischemia and acute radiation syndrome and to trigger regeneration of damaged muscle. One placenta can produce sufficient cells for 20,000 treatments.<\/p>\n<p>Endogenous cardiac stem cells, discovered in 2003, are progenitor cells harboured within the adult mammalian heart that function to replenish adult mammalian cardiomyocytes lost by wear and tear and injury throughout the adult life of the heart.<\/p>\n<p>Biotechnology companies are more and more involved in adoptive cell therapies for solid tumours. Adoptive Cell Therapy (ACT) are engineered cells, wherein a patient\u2019s circulating lymphocytes are isolated, genetically modified with retroviruses to recognize tumour cells (Gene Therapy), expanded and then transfused into the patient.<\/p>\n<p><strong>ACT uses:<\/strong><\/p>\n<ul>\n<li>T-cell receptor (TCR) engineered T cells<\/li>\n<li>Tumour infiltrating lymphocytes (TILs)<\/li>\n<li>Chimeric Antigen Receptor-modified T cells (CAR-T) to enable their effector function<\/li>\n<\/ul>\n<p>There are close to 40 companies developing redirected T cells or NK cells for therapeutic use.<\/p>\n<p>There are also 800+ cell therapy clinical trials underway around the world.<\/p>\n<p>Cell-based therapeutics currently hold great hope of bringing revolutionary cures to patients and are the basis for pioneering approaches in regenerative medicine.<\/p>\n<p><a href=\"https:\/\/mastercellbank.com\/contact\" target=\"_blank\" rel=\"noopener\">Talk to us about your cord blood banking or DNA storage needs<\/a>.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-parallax-none mid-page-form hundred-percent-fullwidth non-hundred-percent-height-scrolling lazyload\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:50px;padding-right:0px;padding-bottom:50px;padding-left:0px;margin-bottom: 0px;margin-top: 100px;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\" data-bg=\"http:\/\/mastercellbank.com\/wp-content\/uploads\/2017\/09\/contact-form-back-300x63.jpg\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:30px;margin-bottom:30px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\"><\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two white-heading\" style=\"margin-top:50px;margin-bottom:20px;\"><h2 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:28;line-height:1.5;\">Get in touch to discuss your needs today.<\/p>\n<p>Cell Therapy &#8211; DNA Storage, Cord Blood banking<\/h2><\/div><div class=\"fusion-text fusion-text-2\"><p><span class=\"call-now\">Call <strong>+353 53 9161398<\/strong> or email <strong>info@biostor.eu<\/strong><\/span><\/p>\n<\/div><p class=\"wpcf7-contact-form-not-found\"><strong>Error:<\/strong> Contact form not found.<\/p><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":1297,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[813],"tags":[],"yst_prominent_words":[437,438,163,448,268,439,442,435,441,188,443,436,444,434,440],"_links":{"self":[{"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/posts\/1295"}],"collection":[{"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/comments?post=1295"}],"version-history":[{"count":6,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/posts\/1295\/revisions"}],"predecessor-version":[{"id":1861,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/posts\/1295\/revisions\/1861"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/media\/1297"}],"wp:attachment":[{"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/media?parent=1295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/categories?post=1295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/tags?post=1295"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/mastercellbank.com\/wp-json\/wp\/v2\/yst_prominent_words?post=1295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}